H-Ile-Pro-Pro-OH (hydrochloride)

H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE) [1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

Product Specifications

CAS Number

[1208862-61-6]

Product Name Alternative

Floropipamide (dihydrochloride); McN-JR 3345 (dihydrochloride); R 3345 (dihydrochloride),Floropipamide; McN-JR 3345; R 3345

UNSPSC

12352209

Target

Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/h-ile-pro-pro-oh-hydrochloride.html

Purity

98.19

Solubility

DMSO : 36.67 mg/mL (ultrasonic) |H2O : 55 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(O)=O)=O)[C@H]([C@@H](C)CC)N.Cl

Molecular Formula

C16H28ClN3O4

Molecular Weight

361.86

References & Citations

[1]Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37 (8) :703-7.|[2]Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78 (4) :777-83.