EAPB 02303

EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations[1].

Product Specifications

CAS Number

[1958290-51-1]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eapb-02303.html

Purity

98.05

Solubility

H2O : 30 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C=C1)=C(O)C=C1C2=CN=C3C(NC)=NC4=CC=CC=C4N32

Molecular Formula

C17H14N4O2

Molecular Weight

306.32

References & Citations

[1]Bigot K, et al. Imiqualines for pancreatic cancer: first-in-class potent and synergistic inhibitors of microtubule polymerisation[J]. Cancer Research, 2023, 83 (7_Supplement) : 5729-5729.