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Org 43553

Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC50 values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine[1].

Product Specifications

CAS Number

501444-88-8

UNSPSC

12352005

Target

Estrogen Receptor/ERR; GnRH Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/org-43553.html

Purity

99.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N)C2=C(C3=CC=CC(NC(CN4CCOCC4)=O)=C3)N=C(SC)N=C2S1)NC(C)(C)C

Molecular Formula

C24H30N6O3S2

Molecular Weight

514.66

References & Citations

[1]van de Lagemaat R, et al. Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor. Hum Reprod. 2009 Mar;24 (3) :640-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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