Sucrose octasulfate (sodium)

Sucrose octasulfate sodium, a derivative of sulfated oligosaccharides, is a matrix metalloproteinase (MMP) inhibitor. Sucrose octasulfate sodium stimulates the release of somatostatin-like immunoreactivity (SLI) from the stomach by acting directly on D cells in the gastric mucosa. Sucrose octasulfate sodium exerts its ulcer-healing effect by releasing endogenous gastric somatostatin. Sucrose octasulfate sodium can be used as a pharmaceutical excipient and significantly improves wound closure in diabetic foot ulcers caused by nerve ischemia and venous leg ulcers. Sucrose octasulfate sodium can be used in the study of chronic wound healing[1][2][3].

Product Specifications

CAS Number

[74135-10-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MMP; Somatostatin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sucrose-octasulfate-sodium.html

Purity

98.0

Solubility

H2O : 116.67 mg/mL (ultrasonic)

Smiles

O=[S](OC[C@]([C@H]([C@@H]1O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)(O[C@@H]1CO[S](=O)(O[Na])=O)O[C@@H](O[C@@H]2CO[S](=O)(O[Na])=O)[C@@H]([C@H]([C@@H]2O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)O[S](=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C12H14Na8O35S8

Molecular Weight

1158.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Lucey MR, et al. Sucrose octasulfate stimulates gastric somatostatin release. Am J Med. 1991 Aug 8;91 (2A) :52S-57S.|[2]Edmonds M, et al. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer) : an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 2018 Mar;6 (3) :186-196.|[3]Dissemond J, et al. Sucrose Octasulfat – Evidenz in der Behandlung chronischer Wunden [Sucrose octasulfate-evidence in the treatment of chronic wounds]. Hautarzt. 2020 Oct;71 (10) :791-801. German.