ATX-II (TFA)
ATX-II TFA is a specific Na+ channel Modulator toxin that can be isolated from the venom of sea anemone (Anemonia sulcata) . ATX-II TFA causes delayed inactivation of the Na+[1][2].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atx-ii-tfa.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CSSC[C@@H]2NC3=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC=N4)C(NCC(N5[C@@H](CCC5)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@H]3CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(NCC(N9[C@@H](CCC9)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC%10=CNC%11=CC=CC=C%10%11)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)NC2=O)C(N%12[C@@H](CCC%12)C(N[C@@H](CO)C(NCC(N[C@@H](CC%13=CNC%14=CC=CC=C%13%14)C(N[C@@H](CC%15=CNC=N%15)C(N[C@H]8CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN.OC(C(F)(F)F)=O.[x]
Molecular Formula
C213H323N63O61S6.xC2HF3O2
Molecular Weight
4934.62 (free acid)
References & Citations
[1]Fletcher JE, et al. ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine. Anesthesiology. 1999 May;90 (5) :1294-301.|[2]Lu YY, et al. ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome. Eur J Clin Invest. 2012 Aug;42 (8) :823-31.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY400062 100 µg
alpha 1 Glycine Receptor (GLRA1) (NM_000171) Human Over-expression Lysate
Sign In for Pricing
View Details 
