Dizocilpine (maleate)

Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.

Product Specifications

CAS Number

[77086-22-7]

Product Name Alternative

(+) -MK 801 Maleate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/__addition__-MK-801-Maleate.html

Purity

99.99

Solubility

DMSO : 133.33 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic) |H2O : 7.69 mg/mL (ultrasonic)

Smiles

C[C@]12C3=CC=CC=C3C[C@@H](N2)C4=CC=CC=C14.O=C(O)/C=C\C(O)=O

Molecular Formula

C20H19NO4

Molecular Weight

337.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Wong EH, et al. The anticonvulsant MK-801 is a potent N-Me-D-Asp antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83 (18) :7104-8.|[2]Wegener N, et al. Evaluation of brain pharmacokinetics of (+) MK-801 in relation to behaviour. Neurosci Lett. 2011 Sep 26;503 (1) :68-72. |[3]Huettner JE, et al. Block of N-Me-D-Asp-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A. 1988 Feb;85 (4) :1307-11.|[4]Thomas DM, et al. MK-801 and dextromethorphan block microglial activation and protect against neurotoxicity. Brain Res. 2005 Jul 19;1050 (1-2) :190-8.|[5]Brown TE, et al. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem. 2008 Dec 2;15 (12) :857-65.|[6]Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-Me-D-Asp receptor activation. Neuroreport. 2017 May 24;28 (8) :444-450.|[7]Iijima Y, et al. Modification by MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist sensitization: evaluation by ambulation in mice. Nihon Shinkei Seishin Yakurigaku Zasshi. 1996 Feb;16 (1) :11-8.