Norneostigmine
Norneostigmine is a potent inhibitor of AChE that can penetrate the blood-brain barrier. Norneostigmine can achieve a 50% inhibition rate of mouse brain AChE after 10 min treatment, which is close to the inhibitory effect of tetrahydroaminoacridine (57% at 10 min) . Norneostigmine can be used to study memory disorders related to Alzheimer's disease and other memory disorders[1].
Product Specifications
CAS Number
[16088-19-0]
UNSPSC
12352005
Hazard Statement
H300-H310-H330
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Purity
98.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N(C)C)OC1=CC=CC(N(C)C)=C1
Molecular Formula
C11H16N2O2
Molecular Weight
208.26
Precautions
P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P405-P501
References & Citations
[1]Arnal F, et al. Studies on new, centrally active and reversible acetylcholinesterase inhibitors. Neurochem Res. 1990 Jun;15 (6) :587-91.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
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