N-Deacetyl-N-formylcolchicine
N-Deacetyl-N-formylcolchicine (N-Formyl-N-deacetylcolchicine, Compound 11) is a selective inhibitor targeting the colchicine-binding site of tubulin. N-Deacetyl-N-formylcolchicine shows antiproliferative activity against various cancer cell lines with IC50 values of 32.61-100.28 nM. N-Deacetyl-N-formylcolchicine inhibits microtubule polymerization to block cell division, induces cancer cell apoptosis and suppresses migration. N-Deacetyl-N-formylcolchicine is promising for research of cancers such as lung cancer and various solid tumors[1].
Product Specifications
CAS Number
[7411-12-3]
Product Name Alternative
N-Formyl-N-deacetylcolchicine
UNSPSC
12352005
Hazard Statement
H300-H318-H330-H340
Target
Apoptosis; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)NC=O)=C3)=CC=C(OC)C3=O
Molecular Formula
C21H23NO6
Molecular Weight
385.41
Precautions
P260-P264-P270-P271-P280-P284-P304+P340-P305+P351+P338-P330-P403+P233-P405-P501
References & Citations
[1]Goel B, et al. Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development. ACS Omega. 2022 Aug 12;7 (33) :28994-29001.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
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