N-Desmethyl diltiazem (hydrochloride)

N-Desmethyl diltiazem hydrochloride is a substrate for CYP3A7 metabolism, which is the predominant fetal form and is minimally expressed in adults[1].

Product Specifications

CAS Number

[130606-60-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Purity

90.0

Smiles

[H]Cl.CC(O[C@@H]1[C@H](C2=CC=C(C=C2)OC)SC3=CC=CC=C3N(C1=O)CCNC)=O

Molecular Formula

C21H25ClN2O4S

Molecular Weight

436.95

Precautions

H302

References & Citations

[1]Williams JA, et al. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30 (8) :883-91.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP3

Available Sizes

Curated Selection

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