N-Methylparoxetine

N-Methylparoxetine is a derivative of Paroxetine that induces Apoptosis NSCLC cells by activating mitogen-activated protein kinase (MAPK) . N-Methylparoxetine has antitumor activity[1].

Product Specifications

CAS Number

[110429-36-2]

UNSPSC

12352005

Hazard Statement

H301, H410

Target

Apoptosis; Autophagy; p38 MAPK

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C1)CC[C@@H](C2=CC=C(C=C2)F)[C@@H]1COC3=CC=C(OCO4)C4=C3

Molecular Formula

C20H22FNO3

Molecular Weight

343.39

Precautions

H301, H410

References & Citations

[1]Wang K, et al. N-Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Jul 11;20 (14) :3415.