DPP-4-IN-18

DPP-4-IN-18 (Sitagliptin impurity 3) (Compound 4) impurity 3 is a potent, selective and orally active DPP-4 inhibitor with an IC50 of 27 nM. DPP-4-IN-18 can effectively prevent DPP-4 from degrading glucagon-like peptide 1 (GLP-1), thereby increasing the level of active GLP-1. DPP-4-IN-18 can be used for the research of type 2 diabetes[1].

Product Specifications

CAS Number

[486460-31-5]

Product Name Alternative

Sitagliptin impurity 3

UNSPSC

12352005

Hazard Statement

H319-H373

Target

Dipeptidyl Peptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=CC=C3F

Molecular Formula

C16H16F5N5O

Molecular Weight

389.32

Precautions

P260-P264-P280-P305+P351+P338-P501

References & Citations

[1]Thornberry NA, et al. Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Curr Top Med Chem. 2007;7 (6) :557-68.