(R) -Verapamil
(R) -Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil. (R) -Verapamil has a relatively low affinity for L-type calcium channels (Cav1.2) (IC50 > 300 μM), and its IC50 for sodium channels (sodium channel) is 3.19 μM. (R) -Verapamil exhibits SSTR2 agonistic activity, with an EC50 of 1.3 μM. (R) -Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R) -Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp)[2][3].
Product Specifications
CAS Number
38321-02-7
Product Name Alternative
Dexverapamil
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Arrestin; Calcium Channel; P-glycoprotein; Potassium Channel; Somatostatin Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Metabolic Disease
Smiles
COC(C=C1CCN(C)CCC[C@](C#N)(C2=CC(OC)=C(C=C2)OC)C(C)C)=C(C=C1)OC
Molecular Formula
C27H38N2O4
Molecular Weight
454.60
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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