N-Methylpyrrolidone-d9

N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2][3][4].

Product Specifications

CAS Number

[185964-60-7]

Product Name Alternative

NMP-d9; 1-Methyl-2-pyrrolidinone-d9

UNSPSC

12352005

Hazard Statement

H227, H315, H319, H335, H360

Target

Biochemical Assay Reagents; Isotope-Labeled Compounds

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.00

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C1N(C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H]

Molecular Formula

C5D9NO

Molecular Weight

108.19

Precautions

H227, H315, H319, H335, H360

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Malek DE, et al. Repeated dose toxicity study (28 days) in rats and mice with N-methylpyrrolidone (NMP) . Drug Chem Toxicol. 1997 Feb-May;20 (1-2) :63-77. |[3]Malley LA, et al. 90-day subchronic toxicity study in rats and mice fed N-methylpyrrolidone (NMP) including neurotoxicity evaluation in rats. Drug Chem Toxicol. 1999 Aug;22 (3) :455-80. |[4]Jing Wang, et al. Nitrate stimulation of N-Methylpyrrolidone biodegradation by Paracoccus pantotrophus: Metabolite mechanism and Genomic characterization. Bioresour Technol. 2019 Dec;294:122185.|[5]Claudia Julieta Solís-González, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2017 Dec 15;84 (1) :e02136-17.