Isobutyramide
Aldehyde Dehydrogenase Isobutyramide is an orally active liver alcohol dehydrogenase (LADH2) inhibitor. Isobutyramide inhibits ethanol metabolism and enhances differentiation-related gene expression, inducing cell cycle arrest and significantly reducing the growth rate of prostate cancer cells (LNCaP) . Isobutyramide is promising for research of advanced prostate cancer[1][2].
Product Specifications
CAS Number
[563-83-7]
UNSPSC
12352211
Hazard Statement
H302
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
99.66
Smiles
O=C(N)C(C)C
Molecular Formula
C4H9NO
Molecular Weight
87.12
Precautions
H302
References & Citations
[1]Chadha VK, et al. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism. J Med Chem. 1983 Jun;26 (6) :916-22.|[2]Gleave ME, et al. Butyrate analogue, isobutyramide, inhibits tumor growth and time to androgen-independent progression in the human prostate LNCaP tumor model. J Cell Biochem. 1998 Jun 1;69 (3) :271-81.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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