Ethylenediaminetetraacetic acid-d16

Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

Product Specifications

CAS Number

[203805-96-3]

Product Name Alternative

EDTA-d16

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Neurological Disease

Purity

99.1

Solubility

10 mM in DMSO

Smiles

[2H]OC(C([2H])([2H])N(C([2H])([2H])C(O[2H])=O)C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C(O[2H])=O)C([2H])([2H])C(O[2H])=O)=O

Molecular Formula

C10D16N2O8

Molecular Weight

308.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412 (1) :34-9. |[3]Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 200745 (5) :565-76. |[4]Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb10 (1) :58-62.