Ethylenediaminetetraacetic acid

Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium) . Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[60-00-4]

Product Name Alternative

EDTA

UNSPSC

12352200

Hazard Statement

H319, H402

Target

Bacterial; Biochemical Assay Reagents; SOD

Related Pathways

Anti-infection; Immunology/Inflammation; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Neurological Disease; Cardiovascular Disease; Cancer

Purity

98.0

Solubility

0.1 M NaOH : 6.67 mg/mL (ultrasonic; warming; adjust pH to 7 with NaOH; heat to 60°C)

Smiles

O=C(O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O

Molecular Formula

C10H16N2O8

Molecular Weight

292.24

Precautions

H319, H402

References & Citations

[1]Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412 (1) :34-9. |[2]Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45 (5) :565-76. |[3]Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10 (1) :58-62. |[4]Gray GW, et al. The effect of ethylenediaminetetra-acetic acid on the cell walls of some gram-negative bacteria. J Gen Microbiol. 1965 Jun;39 (3) :385-99. |[5]González-Cuevas J, et al. Ethylenediaminetetraacetic acid induces antioxidant and anti-inflammatory activities in experimental liver fibrosis. Redox Rep. 2011;16 (2) :62-70. |[6]Naghipour D, et al. Remediation of heavy metals contaminated silty clay loam soil by column extraction with ethylenediaminetetraacetic acid and nitrilo triacetic acid[J]. Journal of Environmental Engineering, 2017, 143 (8) : 04017026.|[7] Deai M, et al. Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells. Biochem Biophys Res Commun. 2022 Oct 20;626:15-20.