Trans-Chalcone (Standard)

Trans-Chalcone (Standard) is the analytical standard of trans-Chalcone (HY-Y0598) . This product is intended for research and analytical applications. trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity[1][2][3].

Product Specifications

CAS Number

[614-47-1]

Target

Apoptosis; Fatty Acid Synthase (FASN) ; Fungal; Reference Standards

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2

Molecular Formula

C15H12O

Molecular Weight

208.26

References & Citations

[1]Luis Felipe Buso Bortolotto, et al. Cytotoxicity of trans-chalcone and licochalcone A against breast cancer cells is due to apoptosis induction and cell cycle arrest. Biomed Pharmacother. 2017 Jan;85:425-433.|[2]Mahmoud Najafian, et al. Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase. Mol Biol Rep. 2011 Mar;38 (3) :1617-20.|[3]Tamires Aparecida Bitencourt, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229.