Benzocaine (hydrochloride) (Standard)
Benzocaine (hydrochloride) is an orally active local agent that can suppress or relieve pain, that acts on voltage-gated Na+ channels at a common receptor, with an IC50 value of 0.8 mM at +30 mV. Additionally, Benzocaine (hydrochloride) non-competitively inhibits Ca-ATPase binding with Ca2+, with an IC50 of 47.1 mM. Benzocaine (hydrochloride) can be used in research within the field of neuromuscular regulation[1][2][3].
Product Specifications
CAS Number
23239-88-5
UNSPSC
12352005
Target
Bacterial; Sodium Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
O=C(OCC)C1=CC=C(N)C=C1.[H]Cl
Molecular Formula
C9H12ClNO2
Molecular Weight
201.65
References & Citations
[1]Wang GK, et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435 (2) :293-302.|[2]Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54 (8) :1322-6.|[3]Di Croce D, et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388 (11) :1163-70.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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