ABS-752 (hydrochloride)
ABS-752 is an orally active prodrug of CRBN-modulating molecular glue targeting. ABS-752 can effectively degrade GSPT1. ABS-752 can degrade NEK7. ABS-752 does not form ternary complexes with CRBN and the neosubstrates. ABS-752 is a prodrug activated by the monoamine oxidase, VAP-1, to an aldehyde intermediate and subsequently to the active molecule, ABT-002. ABS-752 can be used for the study of hepatocellular carcinoma (HCC) [1].
Product Specifications
CAS Number
[2922884-90-8]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Molecular Glues; NEKs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C2=CC(F)=C(CN)C=C2CN1C3C(NC(CC3)=O)=O.Cl
Molecular Formula
C14H15ClFN3O3
Molecular Weight
327.74
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Glaza P, et al. Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC. Commun Chem. 2025 Aug 14;8 (1) :247.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NEK7
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