Thalidomide-piperazine-C-azetidine (TFA)
Thalidomide-piperazine-C-azetidine (TFA) is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
Product Specifications
CAS Number
2791286-89-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC5CNC5)CC4)C=C3C2=O)=O)=O.O=C(C(F)(F)F)O
Molecular Formula
C23H26F3N5O6
Molecular Weight
525.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Frequently Asked Questions
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