(S, R, S) -AHPC-Me-CO-C4-COOH
(S, R, S) -AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12. PROTAC ERα Degrader-12 is a potent and highly selective ERα PROTAC degrader[1].
Product Specifications
CAS Number
2349429-73-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
C([C@@H](NC(CCCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Molecular Formula
C29H40N4O6S
Molecular Weight
572.72
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Wang Y, et al. Targeted Degradation of the Estrogen Receptor α through Unconventional Coactivator Binding Site (CBS) . J Med Chem. 2025 Jul 10;68 (13) :13640-13660.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
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