Thalidomide-5-F-6-azetidin-MeOH
Thalidomide-5-F-6-azetidin-MeOH is a synthesized E3 ligase ligand-linker conjugate that can be used for synthesis of PROTAC FLT3/CHK1 Degrader-1 (HY-178858) . PROTAC FLT3/CHK1 Degrader-1 is a potent FLT3/CHK1 degrader with anti-tumor activity[1].
Product Specifications
CAS Number
[2934621-29-9]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(N4CC(CO)C4)C(F)=C3)=O
Molecular Formula
C17H16FN3O5
Molecular Weight
361.32
References & Citations
[1]Lian X, et al. Development of Dual FLT3 and CHK1 PROTACs for the Treatment of AML. J Med Chem. 2025 Oct 23;68 (20) :21939-21961.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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