BPD
BPD is a COX-2 and TAK1-NF-κB inhibitor, with an IC50 of 18.5 μM for COX-2. BPD inhibits the expression of iNOS, TNF-α, IL-6 and IL-1β at the transcriptional level. BPD has anti-inflammatory activity. BPD can inhibit Carrageenan-induced paw oedema and LPS-induced septic death[1].
Product Specifications
CAS Number
213481-12-0
UNSPSC
12352005
Target
COX; NF-κB
Related Pathways
Immunology/Inflammation; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C1OC(C(C2=CC3=C(OCO3)C=C2)=C1C4=CC=CC=C4)=O
Molecular Formula
C17H10O5
Molecular Weight
294.26
References & Citations
[1]Shin JS, et al. Potent anti-inflammatory effect of a novel furan-2,5-dione derivative, BPD, mediated by dual suppression of COX-2 activity and LPS-induced inflammatory gene expression via NF-κB inactivation. Br J Pharmacol. 2012 Mar;165 (6) :1926-1940.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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