Zindotrine
Zindotrine (MDL-257) is an orally active bronchodilator. Zindotrine is a cGMP phosphodiesterase (PDE) inhibitor. Zindotrine can counteract bronchospasm caused by histamine. Zindotrine can be used to study reversible airflow obstruction, such as asthma[1][2].
Product Specifications
CAS Number
56383-05-2
Product Name Alternative
MDL-257
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
N=1N=C2C(=CC(=NN2C1)N3CCCCC3)C
Molecular Formula
C11H15N5
Molecular Weight
217.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Küng M, et al. The effect of oral zindotrine (MDL-257), a bronchial smooth muscle relaxant, on histamine airways responsiveness in asymptomatic asthmatics. Ann Allergy. 1987 Sep;59 (3) :201-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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