Deoxy-thalidomide-C4-NH2

Deoxy-thalidomide-C4-NH2 is a ligand-linker conjugate for the E3 ligase Cereblon (CRBN) . Deoxy-thalidomide-C4-NH2 can be used in the synthesis of PROTAC BRD4 Degrader (HY-176449) [1].

Product Specifications

CAS Number

[2940934-97-2]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(CCCCN)C=C3C2)=O)=O

Molecular Formula

C17H21N3O3

Molecular Weight

315.37

References & Citations

[1]Lovato K, et al. Reductive C (sp2) -C (sp3) Coupling Protocol to Enable Linker Exploration of Cereblon E3-Ligase BRD4 Proteolysis-Targeting Chimeras. J Med Chem. 2025 May 22;68 (10) :10061-10074.