(S, R, S) -AHPC-Me-10-bromodecanoic acid

(S, R, S) -AHPC-Me-10-bromodecanoic acid is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand 2 (HY-112078) and linker 10-bromoheptanoic acid. (S, R, S) -AHPC-Me-10-bromodecanoic acid can be used for synthesis of PROTAC PI3Kδ degrader-1 (HY-176239) [1].

Product Specifications

CAS Number

[2638512-56-6]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C([C@@H](NC(CCCCCCCCCBr)=O)C(C)(C)C)N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C=C2)C3=C(N=CS3)C)C)=O

Molecular Formula

C33H49BrN4O4S

Molecular Weight

677.74

References & Citations

[1]Yuan B, et al. Lysine-Targeted Covalent Strategy Leading to the Discovery of Novel Potent PROTAC-Based PI3Kδ Degraders. J Med Chem. 2025 Jun 12; 68 (11) :11437-11467.