Apicidin D2
Apicidin D2 (Compound 4), a fungal metabolite, is a Accessory gene regulator A (AgrA) quorum-sensing inhibitor. Apicidin D2 has anti-virulence activity. Apicidin D2 suppresses MRSA agr activation and shows potent inhibitory activities against all agr types in a nonbiocidal manner. Apicidin D2 can be used for MRSA infections research[1].
Product Specifications
CAS Number
[177562-78-6]
UNSPSC
12352100
Target
Bacterial; Endogenous Metabolite
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C1N2[C@@H](C(N[C@@H](CCCCC[C@@H](O)CC)C(N[C@@H](CC3=CN(OC)C4=C3C=CC=C4)C(N[C@H]1[C@@H](CC)C)=O)=O)=O)CCCC2
Molecular Formula
C34H51N5O6
Molecular Weight
625.80
References & Citations
[1]Parlet CP, et al. Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense. Cell Rep. 2019 Apr 2;27 (1) :187-198.e6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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