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CRBN ligand-181

CRBN ligand-181 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

Product Specifications

CAS Number

3036607-12-9

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C(C(C1=C(C)C=C(Br)C=C1F)CC2)NC2=O

Molecular Formula

C12H11BrFNO2

Molecular Weight

300.12

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Miletić N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20 (2) :507-521.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Frequently Asked Questions

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