NH2-MeO-Ph-amide- (2,6-Dioxo-3-Pip)

NH2-MeO-Ph-amide- (2,6-Dioxo-3-Pip) is a CRBN ligand. NH2-MeO-Ph-amide- (2,6-Dioxo-3-Pip) can be used to synthesize PROTAC BRD4 Degrader-22 (HY-155393) [1].

Product Specifications

CAS Number

[1504209-32-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

O=C(NC(CC1)C(NC1=O)=O)C2=CC=C(N)C=C2OC

Molecular Formula

C13H15N3O4

Molecular Weight

277.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Christian Steinebach, et al. Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. J Med Chem. 2023 Oct 30.