Pomalidomide 7'OMe

Pomalidomide 7'OMe is a E3 ligase ligand that can be used in the recruitment of CRBN protein. Pomalidomide 7'OMe can be connected to the BRD9 ligand (HY-107446) by a linker to synthesis of PROTAC BRD9 degrader-9 (HY-177729) [1].

Product Specifications

CAS Number

[2154355-10-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C(OC)=CC=C3N)=O

Molecular Formula

C14H13N3O5

Molecular Weight

303.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bouguenina H, et al. A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity. Chembiochem. 2023 Dec 1;24 (23) :e202300351.