IKP-104

IKP-104 is a microtubule/tubulin inhibitor (IC50 = 1.31 μM) . IKP-104 arrests cells in mitosis and the M phase by inhibiting microtubule polymerization and inducing cytoskeletal microtubule depolymerization. IKP-104 inhibits the growth of mouse and human tumor cell lines. IKP-104 exhibits anti-tumor effects in mouse ascites tumors and lung cancer models. IKP-104 is useful in the research of cancers such as leukemia, lung cancer and melanoma[1][2][3][4].

Product Specifications

CAS Number

[114231-14-0]

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1C(C)=C(C2=CC=C(F)C=C2)N(C3=CC(OC)=CC(OC)=C3Cl)C(C4=CC=CC=C4)=C1

Molecular Formula

C26H21ClFNO3

Molecular Weight

449.90

References & Citations

[1]Mizuhashi F, et al. Antitumor activities of IKP-104, a 4 (1H) -pyrizinone derivative, on cultured and implanted tumors. Jpn J Cancer Res. 1990 Dec;81 (12) :1300-6.|[2]Mizuhashi F, et al. Effects of the tumor inhibitor IKP-104, a 4 (1H) -pyridinone derivative, on cytoskeletal microtubules of cultured tumor cells. Jpn J Cancer Res. 1991 Dec;82 (12) :1442-7.|[3]Mizuhashi F, et al. Interaction of the tumor inhibitor IKP-104, a 4 (1H) -pyridinone derivative, with microtubule proteins. Jpn J Cancer Res. 1992 Feb;83 (2) :211-8.|[4]Khan IA, et al. Differential interaction of tubulin isotypes with the antimitotic compound IKP-104. Biochemistry. 2000 Aug 1;39 (30) :9001-9.