ACI-3024
ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of pathological Tau from different Tauopathies, leading to a significant rescue of the Tau-induced neurodegeneration and neuroinflammation in a cellular model. ACI-3024 is promising for research of neurodegenerative diseases[1].
Product Specifications
CAS Number
[2361566-66-5]
UNSPSC
12352005
Target
Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC=1C=CC2=C(C1)NC3=C2CN(C=4C=CC=5OC(=NC5C4)N6CCOCC6)CC3
Molecular Formula
C22H21FN4O2
Molecular Weight
392.43
References & Citations
[1]Nisbet R M, et al. O5‐06‐04: CHARACTERIZATION OF NOVEL TAU‐SPECIFIC ANTIBODIES AND ENHANCEMENT OF THEIR DELIVERY INTO THE BRAIN USING FOCUSED SCANNING ULTRASOUND[J]. Alzheimer's & Dementia, 2019, 15: P1629-P1630.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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