GR125487
GR125487 is a highly selective and potent 5-HT4 receptor (5-HT4 receptor) antagonist with a Kd value of 0.1 nM. GR125487 has an extremely low affinity for 5-HT3 receptors (Kd > 1 μM) . GR125487 completely antagonizes the memory-promoting effect of BIMU1, and its administration alone has no significant effect on basic social memory. GR125487 can be used for the study of social olfactory memory[1].
Product Specifications
CAS Number
[144625-67-2]
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(OCC1CCN(CCNS(=O)(=O)C)CC1)C2=C(OC)NC=3C=CC(F)=CC32
Molecular Formula
C19H26FN3O5S
Molecular Weight
427.49
References & Citations
[1]Letty S, et al. 5-HT4 receptors improve social olfactory memory in the rat. Neuropharmacology. 1997 Apr-May;36 (4-5) :681-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT4 Receptor
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