(S, R, S) -AHPC-PEG6-Tos
(S, R, S) -AHPC-PEG6-Tos is a combination of a von Hippel-Lindau (VHL) -recruiting ligand and PEGylated crosslinker with a tosyl group. The tosyl group is a good leaving group for nucleophilic substitution reactions. (S, R, S) -AHPC-PEG2-Tos is useful for synthesis of PROTAC compounds and molecules for targeted protein degradation.
Product Specifications
CAS Number
[2839806-94-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
C([C@@H](NC(CCOCCOCCOCCOCCOCCOS(=O)(=O)C1=CC=C(C)C=C1)=O)[C@@](C)(C)C)(=O)N2[C@H](C(NCC3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@@H](O)C2
Molecular Formula
C42H60N4O12S2
Molecular Weight
877.08
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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