Fmoc-PEG2-Val-Cit-PAB-OH
Fmoc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Fmoc protecting group may be removed with piperidine to reveal a primary amine for use in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.
Product Specifications
CAS Number
[2055024-59-2]
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Smiles
OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O)=O
Molecular Formula
C40H52N6O9
Molecular Weight
760.88
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
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