PD 124816

PD 124816 is an orally active fluoroquinolone antibiotic. PD 124816 exerts broad-spectrum antibacterial effects by inhibiting DNA gyrase (topoisomerase IV), and it has no cross-resistance with commonly used antibiotics. PD 124816 is effective against both Gram-positive and Gram-negative bacteria (MIC₉₀ ≤ 0.06 μg/mL), and the MIC₉₀ for anaerobic bacteria (Peptostreptococcus fragi) is 1 μg/mL. PD 124816 exhibits complete bactericidal activity in a mouse model of Mycobacterium leprae infection. PD 124816 can be used for studying mixed infections and infections caused by drug-resistant bacteria[1][2].

Product Specifications

CAS Number

[112654-98-5]

UNSPSC

12352005

Target

Antibiotic; Bacterial; DNA/RNA Synthesis; Topoisomerase

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

FC1=C(C2=C(C(F)=C1N3CC(CC3)N)N)N(C=C(C2=O)C(O)=O)C4CC4

Molecular Formula

C17H18F2N4O3

Molecular Weight

364.35

References & Citations

[1]Cohen MA, et al. In vitro antibacterial activities of the fluoroquinolones PD 117596, PD 124816, and PD 127391. Diagn Microbiol Infect Dis. 1991 May-Jun;14 (3) :245-58. |[2]Gelber RH, et al. Activities of various quinolone antibiotics against Mycobacterium leprae in infected mice. Antimicrob Agents Chemother. 1992 Nov;36 (11) :2544-7.