Dihydrouracil-13C,15N2

Dihydrouracil-13C,15N2 (5,6-Dihydrouracil-13C,15N2) is the 13C- and 15N-labeled Dihydrouracil (HY-W012926) . Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD) -deficient[1][2].

Product Specifications

CAS Number

[181516-96-1]

Product Name Alternative

5,6-Dihydrouracil-13C,15N2

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Smiles

O=C([15NH][13C]1=O)CC[15N]1[H]

Molecular Formula

C3 13CH6 15N2O2

Molecular Weight

117.08

References & Citations

[1]Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84 (12) :2761-2769.|[2]Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74 (6) :737-744.