4-[ (7-Chloro-4-quinolinyl) amino]-1-pentanol-d4

4-[ (7-Chloro-4-quinolinyl) amino]-1-pentanol-d4 is the deuterium labeled Hydroxychloroquine Impurity E (HY-131262) . Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

Product Specifications

CAS Number

[1215752-28-5]

UNSPSC

12352005

Target

Isotope-Labeled Compounds; SARS-CoV; Toll-like Receptor (TLR)

Related Pathways

Anti-infection; Immunology/Inflammation; Others

Field of Research

Others

Smiles

CC(NC1=C2C=CC(Cl)=CC2=NC=C1)CC([2H])(C([2H])(O)[2H])[2H]

Molecular Formula

C14H13D4ClN2O

Molecular Weight

268.78

References & Citations

[1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.|[3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.