Lapatinib-13C2,15N Ditosylate

Lapatinib-13C2,15N Ditosylate is the 13C- and 15N-labeled Lapatinib ditosylate (HY-50898A) . Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].

Product Specifications

CAS Number

[1246819-08-8]

UNSPSC

12352005

Target

Autophagy; EGFR; Ferroptosis; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CC1=CC=C(C=C1)S(=O)(O)=O.FC2=CC(COC3=CC=C(NC4=NC=NC5=CC=C(C=C54)C6=CC=C(O6)C[15NH][13CH2][13CH2]S(C)(=O)=O)C=C3Cl)=CC=C2

Molecular Formula

C34 13C2H34ClFN3 15NO7S2

Molecular Weight

756.24

References & Citations

[1]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1 (2) :85-94