Pemetrexed (disodium) -13C5

Pemetrexed disodium-13C5 (LY231514 disodium-13C5) is the 13C-labeled Pemetrexed disodium (HY-10820A) . Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].

Product Specifications

Product Name Alternative

LY231514 (disodium) -13C5

UNSPSC

12352005

Target

Antifolate; Apoptosis; Autophagy; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N=C(NC2=C1C(CCC3=CC=C(C=C3)C(N[13C@@H]([13CH2][13CH2][13C](O[Na])=O)[13C](O[Na])=O)=O)=CN2)N

Molecular Formula

C15 13C5H19N5Na2O6

Molecular Weight

476.34

References & Citations

[1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57 (6) :1116-23.|[2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185 (2) :956-66.