Cyclic GMP (sodium) -13C5

Cyclic GMP sodium-13C5 is the 13C-labeled Cyclic GMP sodium (HY-113469A) . Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs) . Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4].

Product Specifications

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology; Cardiovascular Disease

Smiles

O=P1(O[13CH2][13C@@H]2[13C@]([H])([13C@H]([13C@@H](O2)N3C=NC4=C3N=C(N)NC4=O)O)O1)O[Na]

Molecular Formula

C5 13C5H11N5NaO7P

Molecular Weight

372.15

References & Citations

[1]Francis SH, et al. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev. 2010 Sep;62 (3) :525-63.|[2]Friebe A, et al. cGMP: a unique 2nd messenger molecule - recent developments in cGMP research and development. Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb;393 (2) :287-302.|[3]Hartzell HC, et al. Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells. Nature. 1986 Sep 18-24;323 (6085) :273-5.|[4]Chintala MS, et al. Cyclic GMP but not cyclic AMP prevents renal platelet accumulation after ischemia-reperfusion in anesthetized rats. J Pharmacol Exp Ther. 1994 Dec;271 (3) :1203-8.