Aficamten-d3
Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) [1].
Product Specifications
Product Name Alternative
CK-274-d3; CK-3773274-d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Myosin
Related Pathways
Cytoskeleton; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(N[C@H]1C2=CC=C(C=C2CC1)C3=NOC(CC)=N3)C4=CN(N=C4)C([2H])([2H])[2H]
Molecular Formula
C18H16D3N5O2
Molecular Weight
340.39
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chihyuan Chuang, et al. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. J Med Chem. 2021 Oct 14;64 (19) :14142-14152.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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