Aficamten-d3

Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) [1].

Product Specifications

Product Name Alternative

CK-274-d3; CK-3773274-d3

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Myosin

Related Pathways

Cytoskeleton; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(N[C@H]1C2=CC=C(C=C2CC1)C3=NOC(CC)=N3)C4=CN(N=C4)C([2H])([2H])[2H]

Molecular Formula

C18H16D3N5O2

Molecular Weight

340.39

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chihyuan Chuang, et al. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. J Med Chem. 2021 Oct 14;64 (19) :14142-14152.