21-Desacetyldeflazacort-d4

21-Desacetyldeflazacort-d4 (21-desDFZ-d4) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085) . 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609) . Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration[1].

Product Specifications

Product Name Alternative

21-desDFZ-d4

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology

Smiles

O=C1C=C[C@]2(C(CC[C@@]3([C@@]2([C@]([2H])(C([2H])([C@]4([C@]3(C[C@@]5([C@]4(N=C(O5)C)C(CO)=O)[H])[H])C)[2H])O)[2H])[H])=C1)C

Molecular Formula

C23H25D4NO5

Molecular Weight

403.50

References & Citations

[1]Möllmann H, et al. Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharm Res. 1995 Jul;12 (7) :1096-100.