Senktide (TFA)
Senktide TFA is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50=0.5-3 nM) . Senktide TFA less potently agonizes the NK1 receptor (EC50=35 µM) . Senktide TFA is promising for research of neurological disease[1][2][3].
Product Specifications
UNSPSC
12352209
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(C(F)(F)F)O.O=C(N(C)[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC1=CC=CC=C1)[C@@H](NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)CC2=CC=CC=C2
Molecular Formula
C42H56F3N7O13S
Molecular Weight
955.99
References & Citations
[1]Byk G, et al. Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P. J Med Chem. 1996 Aug 2;39 (16) :3174-8.|[2]Sarau HM, et al. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther. 1997 Jun;281 (3) :1303-11.|[3]Harrison T, et al. High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template. Bioorg Med Chem Lett. 1998 Jun 2;8 (11) :1343-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK1R; NK3R
Frequently Asked Questions
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