Nalmefene Sulfate-d3

Nalmefene Sulfate-d3 is the deuterium labeled Nalmefene (HY-107744) . Nalmefene is a BBB-penetrable opioid receptor modulator. Nalmefene is an antagonist of MOR and DOR, and a partial agonist of KOR. Nalmefene has anti-inflammatory and neuroprotective activities. Nalmefene can be used in the research of reducing alcohol-dependent disorders[1][2][3][4].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Isotope-Labeled Compounds; NF-κB; NO Synthase; Opioid Receptor; p38 MAPK; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

Related Pathways

Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Smiles

C=C1CC[C@@](O)([C@@H](CC2=C3C(O4)=C(OS(=O)(O)=O)C=C2)N(CC5)C([2H])(C6(CC6)[2H])[2H])[C@@]53[C@]14[H]

Molecular Formula

C21H22D3NO6S

Molecular Weight

422.51

References & Citations

[1]Montesinos J, et al. Nalmefene Prevents Alcohol-Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4. Alcohol Clin Exp Res. 2017 Jul;41 (7) :1257-1270.|[2]Koga M, et al. Nalmefene, an opioid receptor modulator, aggravates atherosclerotic plaque formation in apolipoprotein E knockout mice by enhancing oxidized low-density lipoprotein uptake in macrophages. Biochem Biophys Rep. 2024 Mar 23;38:101688. |[3]Osborn MD, et al. In vivo characterization of the opioid antagonist nalmefene in mice. Life Sci. 2010 Apr 10;86 (15-16) :624-30. |[4]Wang DS, et al. Nalmefene: a long-acting opioid antagonist. Clinical applications in emergency medicine. J Emerg Med. 1998 May-Jun;16 (3) :471-5.