O-Desmethyl midostaurin-13C6
O-Desmethyl midostaurin-13C6 (CGP62221-13C6; O-Desmethyl PKC412-13C6) is the 13C-labeled O-Desmethyl Midostaurin. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM.
Product Specifications
Product Name Alternative
CGP62221-13C6; O-Desmethyl PKC412-13C6
UNSPSC
12352005
Target
Isotope-Labeled Compounds; PKC
Related Pathways
Epigenetics; Others; TGF-beta/Smad
Field of Research
Cancer
Smiles
O[C@@H]1[C@@H](C[C@H]2O[C@@]1(N3C4=C(C5=C3C6=C(C7=C(N26)C=CC=C7)C8=C5CNC8=O)C=CC=C4)C)N(C)C([13C]9=[13CH][13CH]=[13CH][13CH]=[13CH]9)=O
Molecular Formula
C28 13C6H28N4O4
Molecular Weight
562.57
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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