3-Hydroxy Midostaurin-13C6
3-Hydroxy Midostaurin-13C6 (CGP52421-13C6) is the 13C-labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
Product Specifications
Product Name Alternative
CGP52421-13C6
UNSPSC
12352005
Target
FLT3; Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N([C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N3C4=C(C5=C3C6=C(C7=C(N26)C=CC=C7)C8=C5C(NC8=O)O)C=CC=C4)C)[13C]9=[13CH][13CH]=[13CH][13CH]=[13CH]9
Molecular Formula
C29 13C6H30N4O5
Molecular Weight
592.59
References & Citations
[1]Levis M, et al. Plasma inhibitory activity (PIA) : a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108 (10) :3477-83.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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