7a-Hydroxyfrullanolide
7a-Hydroxyfrullanolide has anticancer properties. 7a-Hydroxyfrullanolide reduces polymerization of α-, β-tubulin. 7a-Hydroxyfrullanolide preferrs to bind to β-tubulin over α-tubulin. 7a-Hydroxyfrullanolide also triggers DNA damage response arrests cells in the G2/M-phase. 7a-Hydroxyfrullanolide is an eudesmanolide sesquiterpene lactone (SL) and can be isolated from the flowering plants of the Asteraceae family[1].
Product Specifications
CAS Number
105578-87-8
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Smiles
O[C@]12[C@](OC(C2=C)=O)([H])C3=C(C)CCC[C@@]3(CC1)C
Molecular Formula
C15H20O3
Molecular Weight
248.32
References & Citations
[1]Chimplee S, et al. Anticancer mechanism of 7-α-hydroxyfrullanolide on microtubules and computational prediction of its target binding in triple-negative breast cancer cells. PeerJ. 2022 May 27;10:e13508.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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