Clozapine N-oxide-d8
Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide (HY-17366) . Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
Product Specifications
UNSPSC
12352005
Target
Dopamine Receptor; Drug Metabolite; Isotope-Labeled Compounds; mAChR
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
[O-][N+]1(C)C([2H])(C([2H])(N(C([2H])(C1([2H])[2H])[2H])C2=NC3=C(NC4=CC=CC=C24)C=CC(Cl)=C3)[2H])[2H]
Molecular Formula
C18H11D8ClN4O
Molecular Weight
350.87
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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